Fonction : Professeur des Universités (Pr0 ENSL)
Tél : +33 (0)4 72 72 86 32 Fax : +33 (0)4 26 23 39 47
Mail : ralf.everaers@ens-lyon.fr

Site web perso : https://scholar.google.fr/citations?hl=fr&user=1FybSvAAAAAJ


Unité d'appartenance : Laboratoire de Physique de l'ENS de Lyon

site web: http://www.ens-lyon.fr/PHYSIQUE

Responsable d'unité : Jean-Christophe GEMINARD
Code unité : UMR 5672 Institut : INP Section principale : 2, 5, 7, 10, 11
Ville : Lyon  Délégation régionale : DR07 - Rhône Auvergne


Nom de l'équipe : Physical Genomics

Responsables : Ralf EVERAERS et Benjamin AUDIT


Thématique de l'équipe (< 10 lignes) :
Our team of physicists has general interests in theoretical and computational techniques from Statistical Physics as well as data driven approaches to investigate soft and biological matter with the aim to understand the functional and spatial genome regulation. We are working on a multi-scale description of the structure and dynamics of chromosomes incorporating atomistic simulations of DNA, DNA nanomechanics on the rigid base (pair) level, (torque induced) DNA melting, nucleosome and chromatin structure, chromosome folding and  topological constraints. We perform statistical analysis of genomic data and modeling of nuclear processes. Our main current interests include the effect of chromatin structure on the eukaryotic DNA replication program and the evolutionary implications of sequence-encoded nucleosome positioning.
Current team members are :
Benjamin Audit, Jérémy Barbier, Pascal Carrivain, Ralf Everaers, Ali Farnudi, Elham Ghobadpour, Hadi Kabalane, Max Kolb, Cédric Vaillant

Techniques utilisées :
- Molecular Dynamics, Monte Carlo, transfer matrices, Multi-scale modeling, coarse-grain polymer models, density-functional theory
- Signal and image processing (wavelet transform)
- Bioinformatics and genomics

Mots clés (thématiques et/ou techniques; <10) :
chromatin and nucleosome positioning, multi-scale analysis and modeling, mode DNA replication, nanomechanics, electrostatic interactions, entanglements, epigenetics, genome evolution