Fonction : DR2 CNRS
Tél : 06 59-75-42-70
Mail : olivier.cuvier@gmail.com
Unité d'appartenance : Unité de biologie Moléculaire, cellulaire et du développement - MCD-CBI
Responsable d'unité : Kerstin BYSTRICKY
Code unité : UMR5077 Institut :INSB
Ville : Toulouse Délégation régionale : DRH-Toulouse
Nom de l'équipe : Chromatin Dynamics & Cell proliferation
Responsable : Olivier CUVIER
Site web : http://cbi-toulouse.fr/eng/equipe-cuvier
Thématique de l'équipe (< 10 lignes) :
Our research group has biochemically purified and identified numerous nuclear factors that interact with BEAF/CTCF Drosophila chromatin insulators and that participate to cell programming and the regulation of genes including oncogenes. We are further characterizing the functions of novel insulator factors with respect to a) the regulation of chromatin accessibility, nucleosome-positioning or non-coding RNAs, or b) at higher order scales, the regulation of enhancer-promoter interactions and the compartmentalization of histone marks into 3D epigenetically marked, topological chromatin domains.
Techniques utilisées :
Chromosome Capture Conformation (3C/Hi-C)
Statistical and Bioinformatic approaches
ChIP, Hi-C, Aggregation, RNA-seq, GROseq, ATACseq,
RNAi, Cell Biology, Cytometry, Microscopy, Cytometric microscopy (ScanR)
Mots clés (thématiques et/ou techniques; <10) :
Chromatin insulators, Nucleosome positioning, Nuclear bodies, Long-range DNA interactions, Cell proliferation, Transcriptional pausing
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